Recombinant human ZIP Kinase   

DAPK3; Death associated protein kinase 3; DAP kinase 3; DAP like kinase; Dapk 3; Dapk3; Death associated kinase 3; Death associated protein kinase 3; Dlk; EC 2.7.11.1; FLJ36473; ZIP; ZIP kinase; ZIPK; DAPK3_HUMAN.

濃度：1mg/ ml

來(lái)源：Recombinant Human

純度：≥90% SDS-PAGE

表達(dá)系統(tǒng)：Baculovirus infected Sf9 cells

標(biāo)簽：GST tag N-Terminus  

蛋白長(zhǎng)度：Full length protein

氨基酸：1 to 454

內(nèi)毒素水平：<1.000 Eu/µg

純化方法：HPLC

應(yīng)用：SDS-PAGE，Western blot，ELISA

Biological activity,immunology research

保存：-20℃

保質(zhì)期：1年

 Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.

多克隆抗體

產(chǎn)品名稱：Rabbit Anti-ZIP Kinase  antibody

Rabbit Anti-ZIP Kinase 

別名：DAPK3; Death associated protein kinase 3; DAP kinase 3; DAP like kinase; Dapk 3; Dapk3; Death associated kinase 3; Death associated protein kinase 3; Dlk; EC 2.7.11.1; FLJ36473; ZIP; ZIP kinase; ZIPK; DAPK3_HUMAN.  

來(lái)源：Rabbit

克隆類(lèi)型：Polyclonal

濃度：1mg/ml

亞型：IgG

應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

反應(yīng): predicted: Human,Mouse,Rat,Rabbit,Cow,Chicken,Dog,Horse

理論分子量：52kDa

免疫原：KLH conjugated synthetic peptide derived from human ZIP Kinase

保存：-20℃
保質(zhì)期：1年

單克隆抗體

產(chǎn)品名稱：Anti-ZIP Kinase antibody

Mouse Anti-ZIP Kinase 

別名：DAPK3; Death associated protein kinase 3; DAP kinase 3; DAP like kinase; Dapk 3; Dapk3; Death associated kinase 3; Death associated protein kinase 3; Dlk; EC 2.7.11.1; FLJ36473; ZIP; ZIP kinase; ZIPK; DAPK3_HUMAN. 

來(lái)源：Mouse

克隆類(lèi)型：Monoclonal

濃度：1mg/ml

亞型：IgG

應(yīng)用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500 

反應(yīng):  Human

理論分子量：52kDa

免疫原：KLH conjugated synthetic peptide derived from human ZIP Kinase

保存：-20℃
保質(zhì)期：1年

 Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.